Is the dose of dabigatran really more predictable than warfarin?

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Is Less than 50% More Narcotics Really Noninferior?

epidural infusion, yet the title and abstract only mention the single-injection femoral nerve block (FNB) or adductor canal nerve block (ACB). The patient-controlled epidural analgesia contained 10 μg/ml hydromorphone combined with 0.06% bupivacaine set at 4 ml/h continuous infusion with 4 ml of patient-controlled boluses on demand every 10 min on the day of surgery (postoperative day 0 [POD 0]...

Is less than 50% more narcotics really noninferior?

epidural infusion, yet the title and abstract only mention the single-injection femoral nerve block (FNB) or adductor canal nerve block (ACB). The patient-controlled epidural analgesia contained 10 μg/ml hydromorphone combined with 0.06% bupivacaine set at 4 ml/h continuous infusion with 4 ml of patient-controlled boluses on demand every 10 min on the day of surgery (postoperative day 0 [POD 0]...

Uninterrupted dabigatran is safer than warfarin in patients undergoing ablation for atrial fibrillation

Uninterrupted dabigatran is safer than warfarin in patients undergoing ablation for atrial fibrillation Michael Spartalis, MD, MSc, PhDa,⁎, Eleni Tzatzaki, MD, PhD , Nikolaos I. Nikiteas, MD, MSc, PhD , Eleftherios Spartalis, MD, MSc, PhD b a Division of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece b Laboratory of Experimental Surgery and Surgical Research, University of Athens Me...

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation

BACKGROUND Patients with mechanical heart valves (MHV) require warfarin to prevent thromboembolism. Although dabigatran was as effective as warfarin for stroke prevention in atrial fibrillation when compared with warfarin in patients with MHV, the study was stopped early because of more strokes and bleeding with dabigatran. To determine why dabigatran was less effective than warfarin, we compar...